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KMID : 0357919850190020244
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Korean Journal of Pathology
1985 Volume.19 No. 2 p.244 ~ p.249
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Clear Cell Sarcoma of Tendons and Aponeuroses-A case report with electron microscopic examination-
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Abstract
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Clear cell sarcoma of tendons and aponeuroses is the term coined by Enzinger in 1965
to describe a rare but unique type of soft tissue neoplasm whose cells characteristically
have the capacity to produce melanin.
The authors experienced a case of 64-year old female who presented with a 6×5×4
cm sized mass deeply seated in the left popliteal fossa. The mass was firm and
multinodular, and on cut section revealed patches of brown black pigmentation.
Histologically the tumor was composed of round to fusiform cells with clear or pale
eosinophilic cytoplasm that contained small amounts of glycogen, separated into compact
nests or short fascicles by delicate septa of fibrous tissue. The brown black pigment
seen in tumor cells and stroma was proven to be melanin by special stain, and
ultrastructural examination showed melanosomes in varying stages of development
dispersed freely in the cytoplasm or in the Iysosomes.
These findings strongly support the view that clear cell sarcoma is a tumor of neural
crest origin rather than of tenosynovial mesenchyme origin, and is a soft tissue variant
of malignant melanoma.
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